| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormality of coagulation,
Abnormality of the liver,
Abnormality of the mouth,
Abnormality of the respiratory system,
Abnormality of the vasculature,
Arteriovenous malformation,
Bone pain,
Cavernous hemangioma,
Cerebellar medulloblastoma,
Chronic disseminated intravascular coagulation,
Edema,
Gastrointestinal infarctions,
Glaucoma,
Hemangioma,
Hypermelanotic macule,
Intestinal bleeding,
Intussusception,
Iron deficiency anemia,
Megalocornea,
Mental deterioration,
Microcytic anemia,
Nevus flammeus,
Ocular hypertension,
Pathologic fracture,
Prolonged bleeding time,
Rectal prolapse,
Retinal detachment,
Skin rash,
Subcutaneous nodule,
Thrombocytopenia,
Venous malformation,
Visceral angiomatosis,
Visual loss,
Volvulus
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Mouse (19 sources):
abnormal angiogenesis,
abnormal definitive hematopoiesis,
abnormal heart development,
abnormal pericardium morphology,
abnormal pericyte morphology,
abnormal vascular branching morphogenesis,
abnormal vascular endothelial cell morphology,
abnormal vitelline vascular remodeling,
abnormal vitelline vasculature morphology,
absent myocardial trabeculae,
absent trabeculae carneae,
embryo phenotype,
embryo tissue necrosis,
embryonic growth retardation,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality prior to tooth bud stage,
failure of vascular branching,
no abnormal phenotype detected,
preweaning lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.