| Monarch Ortholog Phenotypes
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Human (1 source):
Eczema
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Mouse (40 sources):
abnormal T cell differentiation,
abnormal bone resorption,
abnormal dermal layer morphology,
abnormal glomerular mesangium morphology,
abnormal hepatocyte morphology,
abnormal involution of the mammary gland,
abnormal liver vasculature morphology,
abnormal lymphopoiesis,
abnormal outer ear morphology,
abnormal plasma cell morphology,
abnormal suckling behavior,
abnormal tail morphology,
arrested B cell differentiation,
decreased birth body size,
decreased body size,
decreased bone trabecula number,
decreased cellular hemoglobin content,
decreased circulating parathyroid hormone level,
decreased compact bone volume,
decreased fetal size,
decreased mean corpuscular volume,
decreased thymocyte number,
decreased triglyceride level,
decreased urine urea nitrogen level,
dilated liver sinusoidal spaces,
ear inflammation,
increased IgG1 level,
increased IgG2a level,
increased alkaline phosphatase activity,
increased anti-nuclear antigen antibody level,
increased circulating alkaline phosphatase level,
increased double-negative T cell number,
increased erythrocyte cell number,
increased liver regeneration,
increased plasma cell number,
liver hyperplasia,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
skin lesions,
small thymus
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.