| Monarch Ortholog Phenotypes
|
Human (50 sources):
Abnormal cardiovascular system morphology,
Abnormal penis morphology,
Abnormal vagina morphology,
Abnormality of the adrenal glands,
Abnormality of the endocrine system,
Abnormality of the genital system,
Abnormality of the ovary,
Acne,
Adrenal gland agenesis,
Amenorrhea,
Aplasia of the uterus,
Aplasia of the vagina,
Aplasia/Hypoplasia of the fallopian tube,
Bilateral lung agenesis,
Brachydactyly,
Cleft lip,
Cleft palate,
Congenital diaphragmatic hernia,
Cubitus valgus,
Facial hirsutism,
Frontal balding,
Growth delay,
High anterior hairline,
Hirsutism,
Hypoplasia of the bladder,
Hypoplasia of the uterus,
Hypospadias,
Increased serum testosterone level,
Intrauterine growth retardation,
Low-set ears,
Malrotation of small bowel,
Obesity,
Oligohydramnios,
Orofacial cleft,
Ovotestis,
Primary amenorrhea,
Protruding ear,
Pulmonary artery stenosis,
Pulmonary hypoplasia,
Pulmonic stenosis,
Renal agenesis,
Sex reversal,
Shield chest,
Short neck,
Short philtrum,
Short stature,
Synophrys,
Thick eyebrow,
Unilateral renal agenesis,
Ventricular septal defect
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Mouse (55 sources):
abnormal adenohypophysis morphology,
abnormal bone marrow morphology,
abnormal chondrocyte morphology,
abnormal craniofacial bone morphology,
abnormal female germ cell morphology,
abnormal kidney development,
abnormal kidney mesenchyme morphology,
abnormal metanephric mesenchyme morphology,
abnormal nephrogenic mesenchyme morphogenesis,
abnormal oogenesis,
abnormal ovary development,
abnormal pubis morphology,
abnormal reproductive system development,
abnormal secondary sex determination,
absent Mullerian ducts,
absent ovary capsule,
axial skeleton hypoplasia,
decreased areal bone mineral density,
decreased bone mineral density of femur,
decreased bone trabecula number,
decreased chondrocyte proliferation,
decreased compact bone area,
decreased gonadotroph cell number,
decreased litter size,
decreased locomotor activity,
decreased mature ovarian follicle number,
decreased oocyte number,
decreased ovary weight,
decreased renal glomerulus number,
decreased somatotroph cell number,
decreased thymocyte number,
decreased thyrotroph cell number,
decreased trabecular bone mass,
delayed endochondral bone ossification,
delayed kidney development,
disheveled coat,
disorganized long bone epiphyseal plate,
disproportionate dwarf,
domed cranium,
increased width of hypertrophic chondrocyte zone,
long incisors,
neonatal lethality, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
oocyte degeneration,
postnatal lethality, complete penetrance,
premature death,
primary sex reversal,
reproductive system phenotype,
secondary sex reversal,
short lumbar vertebrae,
small frontal bone,
small kidney,
small metanephros,
small occipital bone
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.