sox17a Phenotypes

Summary

Expression

Phenotypes

Gene Literature (161)

XB-GENEPAGE-484294

Gene Symbol: sox17a Gene Name: SRY-box 17 alpha

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sox17a manipulated (12 sources), sox17a assayed (24 sources)
Computed annotations: sox17a manipulated (6 sources), sox17a assayed (25 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + sox17a MO + sox17b.1/b.2 MO (13 sources), Xla Wt + sox17a MO + sox17b.1 MO (3 sources), Xla Wt + sox17a MO + sox17b.1 MO (2 sources), Xla Wt + sox17a (1 source), Xla Wt + sox17a + animal cap explant (1 source), Xla Wt + sox17adel_987_1002 + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (48 sources): abnormal abdominal aorta morphology, abnormal artery morphology, abnormal bile duct development, abnormal blood vessel endothelium morphology, abnormal cystic duct morphology, abnormal embryo turning, abnormal embryonic hematopoiesis, abnormal endoderm development, abnormal enzyme/coenzyme level, abnormal extrahepatic bile duct morphology, abnormal foregut morphology, abnormal gallbladder epithelium morphology, abnormal gallbladder size, abnormal gallbladder smooth muscle morphology, abnormal hepatobiliary system morphology, abnormal hepatocyte morphology, abnormal hindgut morphology, abnormal liver development, abnormal liver lobule morphology, abnormal midgut morphology, abnormal peroxisome morphology, abnormal rostral-caudal axis patterning, abnormal thoracic aorta morphology, abnormal vascular smooth muscle morphology, decreased birth body size, decreased bone marrow cell number, decreased circulating ketone body level, decreased endothelial cell proliferation, decreased fasting circulating glucose level, decreased hematopoietic stem cell number, decreased liver triglyceride level, decreased liver weight, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, failure of initiation of embryo turning, increased bile salt level, increased circulating alanine transaminase level, increased circulating alkaline phosphatase level, increased vascular permeability, liver hypoplasia, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, ovary atrophy, perinatal lethality, incomplete penetrance, postnatal lethality, complete penetrance, reduced female fertility, small gallbladder, thin endoderm [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (48 sources): abnormal abdominal aorta morphology, abnormal artery morphology, abnormal bile duct development, abnormal blood vessel endothelium morphology, abnormal cystic duct morphology, abnormal embryo turning, abnormal embryonic hematopoiesis, abnormal endoderm development, abnormal enzyme/coenzyme level, abnormal extrahepatic bile duct morphology, [+]