fn1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (382)

XB-GENEPAGE-484446

Gene Symbol: fn1 Gene Name: fibronectin 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell adhesion (7 sources), decreased cell adhesion in mesodermal cell (3 sources), abnormal axial mesoderm (1 source), abnormal axial mesoderm morphology (1 source), abnormal incomplete closing of the neural tube (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), abnormally split primary heart field (1 source), increased cell population proliferation (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal cell adhesion (7 sources), decreased cell adhesion in mesodermal cell (3 sources), abnormal axial mesoderm (1 source), abnormal axial mesoderm morphology (1 source), abnormal incomplete closing of the neural tube (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), abnormally split primary heart field (1 source), increased cell population proliferation (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: fn1 manipulated (9 sources), fn1 assayed (10 sources)
Computed annotations: fn1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + fn1 MO (4 sources), Xla Wt + fn1 MO + sdc4 MO (3 sources), Xla Wt + fn1 MO (2 sources), Xla Wt + fn1 MO (2 sources), Xla Wt + KD-Pak1 + fn1 MO (2 sources), Xla Wt + adam11 MO + cnc explant + fibronectin (1 source), Xla Wt + KD-Pak1 + fn1 MO + cdh3 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (65 sources): abnormal amnion morphology, abnormal atrioventricular cushion morphology, abnormal cardiac jelly morphology, abnormal cardiac outflow tract development, abnormal developmental patterning, abnormal dorsal aorta morphology, abnormal embryonic neuroepithelium morphology, abnormal embryonic tissue morphology, abnormal endocardium morphology, abnormal extracellular matrix morphology, abnormal extraembryonic tissue morphology, abnormal gastrulation, abnormal heart development, abnormal lateral plate mesoderm morphology, abnormal mesoderm development, abnormal notochord morphology, abnormal placenta vasculature, abnormal protein level, abnormal response to injury, abnormal rostral-caudal patterning of the somites, abnormal vascular development, abnormal vascular smooth muscle morphology, abnormal vasculogenesis, abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, absent limb buds, absent notochord, absent somites, absent visceral yolk sac blood islands, absent vitelline blood vessels, cardiovascular system phenotype, craniofacial phenotype, decreased embryo size, decreased fibroblast proliferation, decreased susceptibility to induced thrombosis, disorganized yolk sac vascular plexus, distended pericardium, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, complete penetrance, failure of chorioallantoic fusion, failure of initiation of embryo turning, head mesenchyme hypoplasia, homeostasis/metabolism phenotype, immune system phenotype, impaired wound healing, incomplete embryo turning, incomplete somite formation, increased cerebral infarct size, increased neuron apoptosis, increased susceptibility to ischemic brain injury, increased tail bud apoptosis, kinked neural tube, kinked tail, no abnormal phenotype detected, premature death, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, reproductive system phenotype, short rostral-caudal axis, skeleton phenotype, skin lesions, thick myocardium [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (65 sources): abnormal amnion morphology, abnormal atrioventricular cushion morphology, abnormal cardiac jelly morphology, abnormal cardiac outflow tract development, abnormal developmental patterning, abnormal dorsal aorta morphology, abnormal embryonic neuroepithelium morphology, abnormal embryonic tissue morphology, abnormal endocardium morphology, abnormal extracellular matrix morphology, [+]