lef1 Phenotypes

Phenotypes

XB-GENEPAGE-485516

Gene Symbol: lef1 Gene Name: lymphoid enhancer binding factor 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally ventrally curved tail (2 sources), decreased size of the tail (2 sources), increased size of the head (2 sources), trunk abnormally curved dorsally (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: lef1 manipulated (5 sources)
Computed annotations: lef1 assayed (15 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lef1 MO (7 sources), Xla Wt + lef1 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (42 sources): abnormal craniofacial morphology, abnormal embryo size, abnormal endometrial gland development, abnormal hair follicle development, abnormal hair follicle morphology, abnormal hair follicle orientation, abnormal hippocampus development, abnormal hippocampus region morphology, abnormal mammary gland bud morphology, abnormal myocardial fiber physiology, abnormal retinal vasculature morphology, abnormal skin condition, abnormal vascular regression, absent alveolar process, absent barrels in primary somatosensory cortex, absent dentate gyrus, absent endometrial glands, absent hair follicle melanin granules, absent hippocampus, absent lower incisors, absent mesencephalic trigeminal nucleus, absent teeth, absent upper incisors, absent vibrissae, arrest of tooth development, decreased body size, decreased hair follicle number, decreased prepulse inhibition, decreased ventricle muscle contractility, dilated heart left ventricle, epithelioid cysts, immune system phenotype, increased skin tumor incidence, perinatal lethality, complete penetrance, persistence of hyaloid vascular system, pointed snout, postnatal lethality, complete penetrance, preweaning lethality, complete penetrance, sparse vibrissae, thick skin, thin ventricular wall, underdeveloped hair follicles [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (42 sources): abnormal craniofacial morphology, abnormal embryo size, abnormal endometrial gland development, abnormal hair follicle development, abnormal hair follicle morphology, abnormal hair follicle orientation, abnormal hippocampus development, abnormal hippocampus region morphology, abnormal mammary gland bud morphology, abnormal myocardial fiber physiology, [+]