| Monarch Ortholog Phenotypes
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Human (29 sources):
2-3 toe syndactyly,
Atrial septal defect,
Autistic behavior,
Broad hallux,
Broad thumb,
Cleft palate,
Cleft upper lip,
Coarctation of aorta,
Cutaneous syndactyly,
Deeply set eye,
Gastroesophageal reflux,
Global developmental delay,
High anterior hairline,
Highly arched eyebrow,
Intellectual disability,
Large forehead,
Laterally extended eyebrow,
Low-set ears,
Microcephaly,
Narrow forehead,
Psychomotor retardation,
Sandal gap,
Short 2nd finger,
Short 5th finger,
Short stature,
Sparse eyebrow,
Tented upper lip vermilion,
Upslanted palpebral fissure,
Ventricular septal defect
[+]
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Mouse (9 sources):
absent heart valves,
absent trigeminal ganglion,
decreased fetal size,
embryonic growth retardation,
increased embryonic tissue cell apoptosis,
increased hepatocyte apoptosis,
lethality throughout fetal growth and development, complete penetrance,
small liver,
small trigeminal ganglion
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.