socs3 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-488198

Gene Symbol: socs3 Gene Name: suppressor of cytokine signaling 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: socs3 assayed (3 sources)
Computed annotations: socs3 assayed (30 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (44 sources): abnormal CD4-positive T cell differentiation, abnormal blood cell morphology/development, abnormal bone marrow cell physiology, abnormal definitive hematopoiesis, abnormal embryonic erythropoiesis, abnormal erythropoiesis, abnormal food intake, abnormal granulocyte differentiation, abnormal hematopoietic stem cell morphology, abnormal macrophage physiology, abnormal myelopoiesis, abnormal placenta development, abnormal placenta labyrinth morphology, abnormal placenta morphology, abnormal placenta vasculature, abnormal placental labyrinth vasculature morphology, absent spongiotrophoblast, decreased T cell proliferation, decreased body fat mass, decreased circulating free fatty acids level, decreased embryo size, decreased interleukin-2 secretion, decreased spongiotrophoblast cell number, decreased spongiotrophoblast size, decreased susceptibility to diet-induced obesity, decreased susceptibility to endotoxin shock, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased thymocyte number, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, hematopoietic system phenotype, improved glucose tolerance, increased erythrocyte cell number, increased insulin sensitivity, increased interleukin-2 secretion, increased neutrophil cell number, increased nucleated erythrocyte cell number, increased susceptibility to induced arthritis, increased trophoblast giant cell number, lethality throughout fetal growth and development, incomplete penetrance, liver hypoplasia, no abnormal phenotype detected, prenatal lethality, small liver [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (44 sources): abnormal CD4-positive T cell differentiation, abnormal blood cell morphology/development, abnormal bone marrow cell physiology, abnormal definitive hematopoiesis, abnormal embryonic erythropoiesis, abnormal erythropoiesis, abnormal food intake, abnormal granulocyte differentiation, abnormal hematopoietic stem cell morphology, abnormal macrophage physiology, [+]