Bulbar signs, Cardiac amyloidosis, Cardiomyopathy, Cataract, Constrictive median neuropathy, Corneal ulceration, Cutis laxa, Deficit in phonologic short-term memory, Depression, Dermatological manifestations of systemic disorders, Diffuse skin atrophy, Distal peripheral sensory neuropathy, Dry skin, Dysarthria, Edema, Facial palsy, Generalized amyloid deposition, Glaucoma, Hearing impairment, Keratoconjunctivitis sicca, Lattice corneal dystrophy, Myokymia, Nail dystrophy, Nephrotic syndrome, Orthostatic hypotension due to autonomic dysfunction, Polyneuropathy, Proteinuria, Pruritus, Regional abnormality of skin, Renal insufficiency, Respiratory tract infection, Sleep apnea, Stage 5 chronic kidney disease, Tongue atrophy, Visual impairment, Xerostomia, obsolete Hypotrichosis

abnormal wound healing, impaired neutrophil recruitment, increased cerebral infarct size, increased compact bone thickness, increased neutrophil cell number, increased susceptibility to ischemic brain injury, increased vascular permeability, lethality throughout fetal growth and development, complete penetrance, premature death