socs1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (5)

XB-GENEPAGE-491219

Gene Symbol: socs1 Gene Name: suppressor of cytokine signaling 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: socs1 assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (54 sources): abnormal CD4-positive T cell differentiation, abnormal CD4-positive, alpha beta T cell morphology, abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha beta T cell morphology, abnormal Peyer's patch morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal cytokine level, abnormal follicular B cell morphology, abnormal interleukin level, abnormal lymph node B cell domain morphology, abnormal lymphocyte physiology, abnormal macrophage physiology, abnormal mature B cell morphology, abnormal pulmonary alveolus wall morphology, abnormal spleen white pulp morphology, absent spleen germinal center, absent thymus corticomedullary boundary, decreased CD4-positive, alpha beta T cell number, decreased body size, decreased bone marrow cell number, decreased effector memory T-helper cell number, decreased eosinophil cell number, decreased hematocrit, decreased pre-B cell number, decreased susceptibility to Togaviridae infection induced morbidity/mortality, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased thymocyte number, dermatitis, enlarged lymph nodes, enlarged thymus medulla, heart inflammation, hematopoietic system phenotype, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased NK T cell number, increased activated T cell number, increased circulating interferon-gamma level, increased hepatoma incidence, increased incidence of corneal inflammation, increased regulatory T cell number, increased sensitivity to xenobiotic induced morbidity/mortality, increased spleen red pulp amount, increased susceptibility to injury, no abnormal phenotype detected, postnatal lethality, complete penetrance, premature death, preweaning lethality, complete penetrance, preweaning lethality, incomplete penetrance, salivary gland inflammation, small thymus, thymus atrophy, thymus cortex atrophy [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (54 sources): abnormal CD4-positive T cell differentiation, abnormal CD4-positive, alpha beta T cell morphology, abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD8-positive, alpha beta T cell morphology, abnormal Peyer's patch morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal cytokine level, abnormal follicular B cell morphology, [+]