| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal cerebral white matter morphology,
Broad hallux,
Broad nasal tip,
Clinodactyly,
Delayed speech and language development,
Epicanthus,
Generalized hypotonia,
Global developmental delay,
Hypertelorism,
Intellectual disability,
Microcephaly,
Micrognathia,
Narrow mouth,
Overlapping toe,
Pes planus,
Prominent nose,
Sandal gap,
Short palpebral fissure,
Short stature,
Slender finger,
Small hand,
Strabismus,
Thin upper lip vermilion,
Upslanted palpebral fissure
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Mouse (14 sources):
abnormal bone marrow cell physiology,
abnormal definitive hematopoiesis,
abnormal hematopoietic stem cell physiology,
decreased bone marrow cell number,
decreased common myeloid progenitor cell number,
decreased erythrocyte cell number,
decreased granulocyte number,
decreased hematopoietic stem cell number,
decreased hematopoietic stem cell proliferation,
decreased hemoglobin content,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.