foxi1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-494124

Gene Symbol: foxi1 Gene Name: forkhead box I1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally localised ectodermal cell (2 sources), abnormal axis elongation (1 source), abnormal cell adhesion (1 source), abnormal ciliated epidermal cell (1 source), abnormal development of cement gland (1 source), abnormal development of ectodermal cell (1 source), abnormal development of neural tube (1 source), abnormal ectoderm morphology (1 source), abnormally decreased number of cilium in the ciliated epidermal cell (1 source), abnormally incomplete structure of epidermis (1 source), abnormally increased number of ciliated cell (1 source), abnormally increased number of non-ciliated epithelial cell (1 source), abnormal mesoderm morphology (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the head (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally localised ectodermal cell (2 sources), abnormal axis elongation (1 source), abnormal cell adhesion (1 source), abnormal ciliated epidermal cell (1 source), abnormal development of cement gland (1 source), abnormal development of ectodermal cell (1 source), abnormal development of neural tube (1 source), abnormal ectoderm morphology (1 source), abnormally decreased number of cilium in the ciliated epidermal cell (1 source), abnormally incomplete structure of epidermis (1 source), abnormally increased number of ciliated cell (1 source), abnormally increased number of non-ciliated epithelial cell (1 source), abnormal mesoderm morphology (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the head (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: foxi1 manipulated (10 sources), foxi1 assayed (8 sources)
Computed annotations: foxi1 assayed (30 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dnbmp7.1 + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 (2 sources), Xla Wt + foxi1 MO (2 sources), Xla Wt + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 + foxi1 MO (1 source), Xla Wt + foxi1-GR + DEX (1 source), Xla Wt + foxi1 MO (1 source), Xla Wt + foxi1 MO (1 source), Xla Wt + foxi1 MO + Activin + animal cap explant (1 source), Xla Wt + foxi1 + vegetal hemisphere explant (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + dnbmp7.1 + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 (2 sources), Xla Wt + foxi1 MO (2 sources), Xla Wt + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 MO + animal cap explant (2 sources), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 (1 source), Xla Wt + foxi1 + foxi1 MO (1 source), Xla Wt + foxi1-GR + DEX (1 source), Xla Wt + foxi1 MO (1 source), Xla Wt + foxi1 MO (1 source), Xla Wt + foxi1 MO + Activin + animal cap explant (1 source), Xla Wt + foxi1 + vegetal hemisphere explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (21 sources): Abnormality of metabolism/homeostasis, Abnormality of the inner ear, Abnormal speech pattern, Abnormal vestibular function, Ataxia, Cochlear malformation, Compensated hypothyroidism, Congenital sensorineural hearing impairment, Enlarged vestibular aqueduct, Goiter, Hyperparathyroidism, Hypoplasia of the cochlea, Hypothyroidism, Incomplete partition of the cochlea type II, Intellectual disability, Nephropathy, Respiratory insufficiency, Sensorineural hearing impairment, Thyroid carcinoma, Tracheal stenosis, Vertigo [+]
Mouse (34 sources): abnormal cochlea morphology, abnormal common crus morphology, abnormal epididymis morphology, abnormal kidney collecting duct epithelium morphology, abnormal membranous labyrinth morphology, abnormal sperm physiology, abnormal temporal bone morphology, absent cochlear modiolus, absent endocochlear potential, absent otoliths, absent pinna reflex, behavior/neurological phenotype, circling, deafness, dilated endolymphatic duct, dilated endolymphatic sac, dilated lateral semicircular canal, dilated posterior semicircular canal, enlarged epididymis, enlarged utricle, enlarged vestibular saccule, head tilt, hearing/vestibular/ear phenotype, homeostasis/metabolism phenotype, impaired swimming, increased apoptosis, increased epididymis weight, increased urine pH, inner ear cyst, kinked sperm flagellum, nervous system phenotype, perinatal lethality, incomplete penetrance, renal/urinary system phenotype, reproductive system phenotype [+]
View all ortholog results at Monarch