sipa1l3 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-494439

Gene Symbol: sipa1l3 Gene Name: signal induced proliferation associated 1 like 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal eye morphology (11 sources), decreased size of the eye (10 sources), abnormal development of eye (7 sources), decreased size of the lens (3 sources), abnormal development of lens (2 sources), abnormal lens morphology (2 sources), abnormal retina morphology (2 sources), abnormal development of retinal layer (1 source), abnormal retinal ganglion cell layer morphology (1 source), abnormal retinal pigmented epithelium morphology (1 source), abnormally increased number of apoptotic cell (1 source), abnormally localised retinal ganglion cell layer (1 source), abnormally localised retinal inner nuclear layer (1 source), increased apoptosis in embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal eye morphology (11 sources), decreased size of the eye (10 sources), abnormal development of eye (7 sources), decreased size of the lens (3 sources), abnormal development of lens (2 sources), abnormal lens morphology (2 sources), abnormal retina morphology (2 sources), abnormal development of retinal layer (1 source), abnormal retinal ganglion cell layer morphology (1 source), abnormal retinal pigmented epithelium morphology (1 source), abnormally increased number of apoptotic cell (1 source), abnormally localised retinal ganglion cell layer (1 source), abnormally localised retinal inner nuclear layer (1 source), increased apoptosis in embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sipa1l3 manipulated (7 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
cataract 45 (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + sipa1l3 MO (12 sources), Xla Wt + sipa1l3 MO (6 sources), Xla Wt + epha4 MO + sipa1l3 MO (1 source), Xla Wt + nog + sipa1l3 MO + animal cap explant (1 source), Xla Wt + Rno.sipa1l3 + epha4 MO (1 source), Xla Wt + Rno.sipa1l3R1491* + sipa1l3 MO (1 source), Xla Wt + Rno.sipa1l3R1491* + sipa1l3 MO (1 source), Xla Wt + sipa1l3 MO (1 source), Xla Wt + sipa1l3 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (2 sources): abnormal lens epithelium morphology, abnormal lens fiber morphology