| Monarch Ortholog Phenotypes
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Human (9 sources):
Abnormality of neutrophil physiology,
Immunodeficiency,
Impaired oxidative burst,
Leukocytosis,
Neutrophilia,
Poor wound healing,
Rectal abscess,
Reduction of neutrophil motility,
Urachal cyst
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Mouse (30 sources):
abnormal circulating alanine transaminase level,
abnormal cytotoxic T cell physiology,
abnormal granulocyte differentiation,
abnormal wound healing,
decreased B-1 B cell number,
decreased B-1a cell number,
decreased CD4-positive, alpha beta T cell number,
decreased CD8-positive, naive alpha-beta T cell number,
decreased T cell proliferation,
decreased alpha-beta T cell number,
decreased angiogenesis,
decreased circulating alanine transaminase level,
decreased response to antigen,
decreased spleen weight,
decreased vascular endothelial cell proliferation,
delayed wound healing,
impaired hematopoiesis,
impaired humoral immune response,
impaired natural killer cell mediated cytotoxicity,
increased B-1 B cell number,
increased B-1b cell number,
increased CD8-positive, alpha-beta T cell number,
increased alpha-beta T cell number,
increased central memory CD4-positive, alpha-beta T cell number,
increased central memory CD8 positive, alpha-beta T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased effector memory CD8-positive, alpha-beta T cell number,
increased neutrophil cell number,
increased sensitivity to induced morbidity/mortality,
oxidative stress
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.