| Monarch Ortholog Phenotypes
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Human (41 sources):
Abnormality of body height,
Abnormality of the dentition,
Abnormality of the voice,
Absence of pubertal development,
Absence of secondary sex characteristics,
Anxiety,
Azoospermia,
Breast hypoplasia,
Camptodactyly,
Cleft palate,
Congenital sensorineural hearing impairment,
Cryptorchidism,
Decreased serum testosterone concentration,
Decreased testicular size,
Delayed puberty,
Delayed skeletal maturation,
Depressed nasal bridge,
Depression,
Eunuchoid habitus,
Female hypogonadism,
Generalized joint hypermobility,
Gynecomastia,
Hypertelorism,
Hypogonadotropic hypogonadism,
Hypoplasia of the ovary,
Hypoplasia of the uterus,
Impotence,
Increased female libido,
Infertility,
Male hypogonadism,
Micropenis,
Non-obstructive azoospermia,
Osteopenia,
Osteoporosis,
Phenotypic abnormality,
Primary amenorrhea,
Secondary amenorrhea,
Sparse axillary hair,
Sparse body hair,
Sparse pubic hair,
Wide intermamillary distance
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Mouse (42 sources):
abnormal anogenital distance,
abnormal estrous cycle,
abnormal external male genitalia morphology,
abnormal female reproductive system morphology,
abnormal gametogenesis,
abnormal ovarian follicle number,
abnormal response to injury,
abnormal seminiferous tubule morphology,
abnormal sperm flagellum morphology,
abnormal spermatocyte morphology,
abnormal tertiary ovarian follicle morphology,
absent corpus luteum,
absent estrous cycle,
absent sperm head,
arrest of male meiosis,
arrest of spermatogenesis,
constricted vagina orifice,
decreased circulating dihydrotestosterone level,
decreased circulating estradiol level,
decreased circulating progesterone level,
decreased corpora lutea number,
decreased follicle stimulating hormone level,
decreased luteinizing hormone level,
decreased ovary weight,
decreased testis weight,
delayed vaginal opening,
impaired ovarian folliculogenesis,
increased circulating estradiol level,
increased tertiary ovarian follicle number,
no abnormal phenotype detected,
prolonged estrous cycle,
prolonged estrus,
prolonged metestrus,
reduced female fertility,
reproductive system phenotype,
small epididymis,
small male preputial glands,
small ovary,
small penis,
small seminal vesicle,
small seminiferous tubules,
thin uterus
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.