Decreased circulating total IgM, Decreased lymphocyte proliferation in response to mitogen, Diarrhea, Failure to thrive, Failure to thrive in infancy, Hepatosplenomegaly, Hyperpigmentation of the skin, Impaired lymphocyte transformation with phytohemagglutinin, Intestinal obstruction, Lack of T cell function, Lymphopenia, Meningitis, Panhypogammaglobulinemia, Partial IgA deficiency, Pneumonia, Pustule, Rectovaginal fistula, Recurrent infection of the gastrointestinal tract, Recurrent opportunistic infections, Recurrent pneumonia, Recurrent respiratory infections, Recurrent upper respiratory tract infections, Recurrent viral infections, Severe combined immunodeficiency, Skin rash, T lymphocytopenia

abnormal hematopoietic system morphology/development, abnormal immune system organ morphology, abnormal leukocyte physiology, abnormal lymphocyte physiology, abnormal lymphopoiesis, abnormal mesenteric lymph node morphology, abnormal myelopoiesis, abnormal response to infection, abnormal spleen periarteriolar lymphoid sheath morphology, abnormal spleen white pulp morphology, abnormal splenic cell ratio, abnormal thymus cell ratio, abnormal thymus cortex morphology, abnormal thymus corticomedullary boundary morphology, abnormal thymus medulla morphology, abnormal thymus morphology, absent Hassall's corpuscle, absent lymph nodes, arrested B cell differentiation, chronic inflammation, decreased B-1 B cell number, decreased B-2 B cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased NK T cell number, decreased T cell proliferation, decreased dendritic cell number, decreased hematopoietic stem cell number, decreased immature B cell number, decreased interferon-gamma secretion, decreased mature B cell number, decreased memory B cell number, decreased myeloid dendritic cell number, decreased pre-B cell number, decreased response to antigen, decreased single-positive T cell number, decreased spleen weight, decreased susceptibility to parasitic infection induced morbidity/mortality, decreased thymocyte number, decreased thymus weight, immune system phenotype, impaired hematopoiesis, impaired humoral immune response, increased B-1b cell number, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased macrophage cell number, increased memory B cell number, increased myeloid dendritic cell number, increased neutrophil cell number, increased single-positive T cell number, increased susceptibility to Herpesvirales infection, increased susceptibility to bacterial infection induced morbidity/mortality, premature death, preweaning lethality, incomplete penetrance, small Peyer's patches, small lymph nodes, small spleen, small thymus, small thymus medulla, thymus cortex hypoplasia, vision/eye phenotype