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Summary Expression Phenotypes Gene Literature (33) GO Terms (15) Nucleotides (261) Proteins (40) Interactants (322) Wiki
XB-GENEPAGE-5918987

sqstm1     sequestosome 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal neural tube closure (11 sources), decreased length of anterior-posterior axis (9 sources), abnormal convergent extension involved in axis elongation (4 sources), abnormal incomplete closing of the blastopore (3 sources)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sqstm1 manipulated (2 sources)
Computed annotations: sqstm1 assayed (3 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + sqstm1 MO (9 sources), Xla Wt + Hsa.SQSTM1 (4 sources), Xla Wt + DN-SQSTM1 (3 sources), Xla Wt + sqstm1 MO (2 sources), Xla Wt + vangl2 MO + sqstm1 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (129 sources): Abnormal brain FDG positron emission tomography, Abnormal cerebellum morphology, Abnormal lower motor neuron morphology, Abnormal mitochondrial morphology, Abnormal pyramidal sign, Abnormal upper motor neuron morphology, Abnormality of extrapyramidal motor function, Abnormality of the cerebral white matter, Absent Achilles reflex, Abulia, [+]
Mouse (45 sources): abnormal aerobic respiration, abnormal bone mineralization, abnormal bone remodeling, abnormal brown adipose tissue thermogenesis, abnormal mitochondrial ATP synthesis coupled electron transport, abnormal mitochondrial crista morphology, abnormal mitochondrial physiology, abnormal osteoblast physiology, abnormal osteoclast differentiation, abnormal osteoclast morphology, [+]

View all ortholog results at Monarch