Aggressive behavior, Agitation, Amyotrophic lateral sclerosis, Anxiety, Apathy, Apraxia, Astrocytosis, Babinski sign, Behavioral abnormality, Bilateral sensorineural hearing impairment, Bilateral tonic-clonic seizure, Bone pain, Bulbar palsy, Cerebellar atrophy, Cerebral cortical atrophy, Clumsiness, Cognitive impairment, Collectionism, Degeneration of anterior horn cells, Degeneration of the lateral corticospinal tracts, Depressivity, Difficulty walking, Disinhibition, Distal amyotrophy, Distal muscle weakness, Distal upper limb amyotrophy, Distal upper limb muscle weakness, Dysarthria, Dyscalculia, Dysdiadochokinesis, Dysgraphia, Dyslexia, Dysmetria, Dysphagia, Dysphasia, Dyspnea, Dystonia, EEG with continuous slow activity, EMG: myopathic abnormalities, Echolalia, Elevated alkaline phosphatase, Elevated serum creatine kinase, Emotional blunting, Emotional lability, Facial palsy, Fasciculations, Fatigable weakness of bulbar muscles, Fatigable weakness of respiratory muscles, Fatigable weakness of swallowing muscles, Fatigue, Foot dorsiflexor weakness, Fractures of the long bones, Frontotemporal cerebral atrophy, Frontotemporal dementia, Functional respiratory abnormality, Gait ataxia, Gait disturbance, Generalized amyotrophy, Generalized muscle weakness, Gliosis, Global brain atrophy, Hallucinations, Hearing impairment, Hyperorality, Hyperreflexia, Hyporeflexia, Inappropriate behavior, Intrinsic hand muscle atrophy, Irritability, Lack of insight, Language impairment, Laryngospasm, Limb ataxia, Loss of speech, Memory impairment, Mental deterioration, Mildly elevated creatine kinase, Muscle spasm, Muscle weakness, Mutism, Myopathy, Nausea and vomiting, Neurodegeneration, Neuronal loss in the cerebral cortex, Nystagmus, Oculomotor apraxia, Osteolysis, Osteosarcoma, Pain, Paralysis, Paraparesis, Parkinsonism, Patchy osteosclerosis, Perseveration, Personality changes, Poor speech, Progressive cerebellar ataxia, Proximal muscle weakness, Psychosis, Ptosis, Respiratory insufficiency, Restlessness, Restrictive behavior, Rimmed vacuoles, Scapular winging, Skeletal muscle atrophy, Spasticity, Steppage gait, Stereotypy, Supranuclear gaze palsy, Tetraparesis, Thickened nuchal skin fold, Tremor, Upper motor neuron dysfunction, Urinary incontinence, Vertical supranuclear gaze palsy, Weakness due to upper motor neuron dysfunction, Weakness of long finger extensor muscles, Xerostomia

abnormal osteoclast physiology, abnormal respiratory electron transport chain, behavior/neurological phenotype, cellular phenotype, decreased bone trabecular spacing, decreased circulating glucose level, decreased core body temperature, decreased energy expenditure, decreased interleukin-6 secretion, decreased mean corpuscular hemoglobin, decreased osteoclast cell number, decreased oxygen consumption, disorganized mitochondrial cristae, growth/size/body region phenotype, homeostasis/metabolism phenotype, hypoactivity, increased abdominal adipose tissue amount, increased body length, increased bone mineral density of femur, increased bone trabecula number, increased bone volume, increased brown fat cell lipid droplet size, increased food intake, increased lean body mass, increased neuron number, increased osteoclast cell number, increased susceptibility to age related obesity, increased total body fat amount, increased white fat cell size, liver/biliary system phenotype, oxidative stress, premature aging, premature death, rough coat, skeleton phenotype