| Monarch Ortholog Phenotypes
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Human (21 sources):
Arthritis,
Decreased serum complement C3,
Decreased serum complement factor B,
Decreased serum complement factor H,
Decreased serum complement factor I,
Glomerulonephritis,
Pyelonephritis,
Recurrent Haemophilus influenzae infections,
Recurrent meningitis,
Recurrent meningococcal disease,
Recurrent otitis media,
Recurrent sinusitis,
Recurrent skin infections,
Recurrent streptococcus pneumoniae infections,
Recurrent urinary tract infections,
Renal insufficiency,
Reticular pigmentary degeneration,
Retinal dystrophy,
Sinusitis,
Vasculitis,
Visual impairment
[+]
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Mouse (3 sources):
abnormal renal glomerulus morphology,
decreased circulating complement protein level,
renal glomerular protein deposits
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.