| Monarch Ortholog Phenotypes
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Human (15 sources):
Abnormal autonomic nervous system physiology,
Abnormal cardiac exercise stress test,
Abnormality of prenatal development or birth,
Abnormality of the ear,
Abnormal T-wave,
Hypokalemia,
Prolonged QTc interval,
Prolonged QT interval,
Seizure,
Sinus bradycardia,
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Mouse (22 sources):
abnormal seminiferous tubule morphology,
abnormal Sertoli cell development,
abnormal spermatocyte morphology,
arrest of male meiosis,
arrest of spermatogenesis,
decreased circulating fructosamine level,
decreased circulating glucose level,
decreased lean body mass,
decreased lumbar vertebrae number,
decreased mature B cell number,
decreased percent body fat/body weight,
decreased seminal vesicle weight,
decreased testis weight,
increased carbon dioxide production,
increased CD4-positive, alpha beta T cell number,
increased CD8-positive, alpha-beta T cell number,
increased circulating alkaline phosphatase level,
increased circulating fructosamine level,
increased energy expenditure,
increased oxygen consumption,
lethality, incomplete penetrance,
preweaning lethality, incomplete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.