Areflexia, Ataxia, Babinski sign, Behavioral abnormality, Bilateral sensorineural hearing impairment, Bulbar palsy, Calf muscle hypertrophy, Cerebral cortical atrophy, Degeneration of anterior horn cells, Degeneration of the lateral corticospinal tracts, Depression, Difficulty walking, Disinhibition, Distal lower limb muscle weakness, Distal muscle weakness, Distal sensory impairment, Dysarthria, Dyscalculia, Dysphagia, Dyspnea, Elevated circulating creatine kinase concentration, Emotional lability, Exercise intolerance, Facial palsy, Fasciculations, Fatigable weakness of bulbar muscles, Fatigable weakness of respiratory muscles, Fatigable weakness of swallowing muscles, Fatigue, Frontal lobe dementia, Frontotemporal dementia, Generalized amyotrophy, Generalized muscle weakness, Gliosis, Global brain atrophy, Hallucinations, Hammertoe, Hyporeflexia, Increased circulating lactate concentration, Increased intramyocellular lipid droplets, Increased mitochondrial number, Laryngospasm, Mildly elevated creatine kinase, Muscle spasm, Muscle weakness, Mutism, Nausea and vomiting, Neck flexor weakness, Neurodegeneration, Neuronal loss in the cerebral cortex, Pain, Paralysis, Paraparesis, Parkinsonism, Perseveration, Pes cavus, Pes planus, Progressive cerebellar ataxia, Proximal muscle weakness, Proximal muscle weakness in lower limbs, Proximal muscle weakness in upper limbs, Ptosis, Ragged-red muscle fibers, Respiratory insufficiency, Restrictive ventilatory defect, Sensorineural hearing impairment, Short stature, Skeletal muscle atrophy, Spasticity, Spinal muscular atrophy, Supranuclear gaze palsy, Tetraparesis, Tremor, Weakness due to upper motor neuron dysfunction, Weakness of facial musculature, Xerostomia

cellular phenotype, decreased exploration in new environment, decreased grip strength, decreased skeletal muscle mass, impaired exercise endurance, impaired limb coordination, increased grip strength, increased susceptibility to otitis media, limb grasping, premature death