| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal cardiovascular system morphology,
Abnormal intestine morphology,
Abnormal morphology of female internal genitalia,
Abnormal sacrum morphology,
Abnormality of the uterus,
Cleft palate,
Depressed nasal ridge,
Epicanthus,
Fetal polyuria,
Horseshoe kidney,
Hydronephrosis,
Hypertelorism,
Low-set ears,
Multicystic kidney dysplasia,
Non-midline cleft of the upper lip,
Nonketotic hypoglycemia,
Oligohydramnios,
Pulmonary hypoplasia,
Renal agenesis,
Renal dysplasia,
Sirenomelia,
Tracheoesophageal fistula,
Urogenital fistula,
Vesicoureteral reflux
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Mouse (20 sources):
abnormal embryo size,
abnormal embryo turning,
abnormal forebrain development,
abnormal heart development,
abnormal hindbrain development,
abnormal midbrain development,
abnormal testis development,
abnormal ureteric bud morphology,
abnormal ureteric bud tip morphology,
absent Mullerian ducts,
absent Wolffian ducts,
decreased embryo size,
decreased lean body mass,
double ureter,
embryonic lethality, complete penetrance,
impaired branching involved in ureteric bud morphogenesis,
increased total body fat amount,
liver hypoplasia,
preweaning lethality, complete penetrance,
stomach hypoplasia
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.