Monarch Ortholog Phenotypes
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Human (3 sources):
Focal-onset seizure,
Intellectual disability,
Seizure
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Mouse (27 sources):
abnormal behavioral response to addictive substance,
abnormal brain wave pattern,
abnormal inhibitory postsynaptic currents,
abnormal locomotor activation,
abnormal motor learning,
abnormal nicotine-mediated receptor currents,
abnormal response to new environment,
abnormal synaptic dopamine release,
behavioral arrest,
behavior/neurological phenotype,
clonic seizures,
decreased chemically-elicited antinociception,
decreased dopaminergic neuron number,
decreased grooming behavior,
decreased neurotransmitter release,
enhanced behavioral response to nicotine,
enhanced conditioned place preference behavior,
immune system phenotype,
impaired behavioral response to addictive substance,
impaired behavioral response to nicotine,
impaired conditioned place preference behavior,
increased anxiety-related response,
increased exploration in new environment,
increased susceptibility to pharmacologically induced seizures,
increased vertical activity,
neonatal lethality, complete penetrance,
nervous system phenotype
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View all ortholog results at Monarch
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