| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal cerebral white matter morphology,
Broad hallux,
Broad nasal tip,
Clinodactyly,
Delayed speech and language development,
Epicanthus,
Generalized hypotonia,
Global developmental delay,
Hypertelorism,
Intellectual disability,
Microcephaly,
Micrognathia,
Narrow mouth,
Overlapping toe,
Pes planus,
Prominent nose,
Sandal gap,
Short palpebral fissure,
Short stature,
Slender finger,
Small hand,
Strabismus,
Thin upper lip vermilion,
Upslanted palpebral fissure
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Mouse (28 sources):
abnormal body length,
abnormal chorion morphology,
abnormal developmental patterning,
abnormal digestive system development,
abnormal ectoderm development,
abnormal egg cylinder morphology,
abnormal endoderm development,
abnormal extraembryonic tissue morphology,
abnormal primitive streak elongation,
abnormal primitive streak formation,
abnormal proximal-distal axis patterning,
abnormal rostral-caudal axis patterning,
abnormal visceral endoderm morphology,
absent anterior visceral endoderm,
absent chorion,
absent distal visceral endoderm,
absent mesoderm,
decreased body length,
decreased cell proliferation,
decreased embryo size,
embryonic growth arrest,
embryonic growth retardation,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
failure of primitive streak formation,
preweaning lethality, complete penetrance,
small ectoplacental cone,
thick embryonic epiblast
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.