| Monarch Ortholog Phenotypes
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Human (15 sources):
Abnormality of the nail,
Congenital ichthyosiform erythroderma,
Corneal erosion,
Ectropion,
Erythroderma,
Failure to thrive,
Hearing impairment,
Hypergranulosis,
Hypohidrosis,
Ichthyosis,
[+]
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Mouse (30 sources):
abnormal ceramide level,
abnormal epidermal lamellar body morphology,
abnormal epidermis stratum corneum morphology,
abnormal free fatty acids level,
abnormal keratohyalin granule morphology,
abnormal motor capabilities/coordination/movement,
abnormal skin development,
abnormal sphingomyelin level,
abnormal stratum corneum lipid matrix formation,
abnormal tail tip morphology,
absent gastric milk in neonates,
acanthosis,
decreased birth weight,
decreased embryo size,
decreased embryo weight,
decreased fatty acids level,
decreased keratohyalin granule number,
decreased keratohyalin granule size,
decreased locomotor activity,
epidermal desquamation,
epidermal hyperplasia,
impaired skin barrier function,
impaired stratum corneum desquamation,
increased body length,
increased cholesterol level,
increased triglyceride level,
neonatal lethality, complete penetrance,
postnatal lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
shiny skin
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.