ets1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6465483

Gene Symbol: ets1 Gene Name: v-ets avian erythroblastosis virus E26 oncogene homolog 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased pigmentation in the whole organism (5 sources), decreased size of the head (5 sources), abnormally decreased mobility of migratory neural crest cell (2 sources), abnormally incomplete structure of head (2 sources), abnormally irregular spatial pattern of cranial neural crest (2 sources), abnormally ruffled dorsal fin (2 sources), increased apoptosis in neural plate border (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ets1 manipulated (32 sources), ets1 assayed (3 sources)
Computed annotations: ets1 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ets1 (9 sources), Xla Wt + ets1 (5 sources), Xla Wt + ets1 MO (4 sources), Xla Wt + ets1del_1-450 (4 sources), Xla Wt + ets1del_1-906 (4 sources), Xla Wt + ets1 (3 sources), Xla Wt + ets1 MO (3 sources), Xla Wt + ets1-GR + DEX (3 sources), Xla Wt + ets1 + TSA (2 sources), Xla Wt + ets1 MO (2 sources), Xla Wt + ets1del_1044-1314 (2 sources), Xla Wt + ets1del_783-1314 (2 sources), Xla Wt + ets1-GR + DEX (1 source), Xla Wt + dnets1-GR + DEX (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + ets1 (9 sources), Xla Wt + ets1 (5 sources), Xla Wt + ets1 MO (4 sources), Xla Wt + ets1del_1-450 (4 sources), Xla Wt + ets1del_1-906 (4 sources), Xla Wt + ets1 (3 sources), Xla Wt + ets1 MO (3 sources), Xla Wt + ets1-GR + DEX (3 sources), Xla Wt + ets1 + TSA (2 sources), Xla Wt + ets1 MO (2 sources), Xla Wt + ets1del_1044-1314 (2 sources), Xla Wt + ets1del_783-1314 (2 sources), Xla Wt + ets1-GR + DEX (1 source), Xla Wt + dnets1-GR + DEX (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (1 source): Hepatic fibrosis
Mouse (38 sources): abnormal CD8-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal T cell activation, abnormal leukocyte physiology, abnormal lymphopoiesis, abnormal spleen red pulp morphology, abnormal thymus cortex morphology, abnormal thymus morphology, abnormal thymus subcapsular epithelium morphology, absent B-1a cells, belly spot, decreased B cell proliferation, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased mature B cell number, decreased memory T cell number, decreased pro-B cell number, decreased spleen weight, decreased thymocyte apoptosis, decreased thymocyte number, enlarged thymus, head blaze, hematopoietic system phenotype, immune system phenotype, impaired natural killer cell mediated cytotoxicity, increased B cell apoptosis, increased cell proliferation, increased double-negative T cell number, increased double-positive T cell number, increased plasma cell number, increased pro-B cell number, increased splenocyte apoptosis, increased thymus weight, perinatal lethality, incomplete penetrance, postnatal lethality, incomplete penetrance, prenatal lethality, incomplete penetrance, small spleen, white spotting [+]
View all ortholog results at Monarch