prdm1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-853253

Gene Symbol: prdm1 Gene Name: PR domain 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal tail morphology (1 source), absent swimming behavior (1 source), decreased length of anterior-posterior axis (1 source), decreased length of tail (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: prdm1 assayed (6 sources)
Computed annotations: prdm1 assayed (7 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + prdm1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (53 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal T follicular helper cell differentiation, abnormal aortic valve morphology, abnormal dermomyotome development, abnormal dorsal aorta morphology, abnormal embryo development, abnormal germinal center B cell physiology, abnormal kidney morphology, abnormal left subclavian artery morphology, abnormal memory B cell number, abnormal mesangial cell morphology, abnormal myotome development, abnormal pharyngeal arch mesenchyme morphology, abnormal placenta development, abnormal placenta labyrinth morphology, abnormal placenta morphology, abnormal plasma cell differentiation, abnormal plasma cell morphology, abnormal primordial germ cell migration, abnormal splenocyte physiology, abnormal spongiotrophoblast layer morphology, abnormal third pharyngeal arch morphology, absent oocytes, absent plasma cells, absent primordial germ cells, absent second pharyngeal arch, absent third pharyngeal arch, atrioventricular septal defect, decreased embryo size, decreased plasma cell number, decreased primordial germ cell number, decreased testis weight, decreased trophoblast giant cell number, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, endocrine/exocrine gland phenotype, hematopoietic system phenotype, immune system phenotype, increased T follicular helper cell number, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased autoantibody level, increased germinal center B cell number, increased interleukin-6 secretion, increased spleen germinal center number, increased spleen germinal center size, increased splenocyte number, increased susceptibility to Orthomyxoviridae infection, lethality throughout fetal growth and development, incomplete penetrance, no abnormal phenotype detected, postnatal lethality, incomplete penetrance, prenatal lethality, complete penetrance, uterine hemorrhage [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (53 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal T follicular helper cell differentiation, abnormal aortic valve morphology, abnormal dermomyotome development, abnormal dorsal aorta morphology, abnormal embryo development, abnormal germinal center B cell physiology, abnormal kidney morphology, abnormal left subclavian artery morphology, abnormal memory B cell number, [+]