| Monarch Ortholog Phenotypes
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Human (8 sources):
Amblyopia,
Bilateral ptosis,
Congenital fibrosis of extraocular muscles,
Exotropia,
Hypertropia,
Hypotropia,
Restrictive external ophthalmoplegia,
Visual impairment
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Mouse (28 sources):
abnormal cranial ganglia morphology,
abnormal gluconeogenesis,
abnormal glycogen homeostasis,
abnormal locus ceruleus morphology,
abnormal neuron differentiation,
abnormal oculomotor nerve morphology,
abnormal otic ganglion morphology,
abnormal parasympathetic ganglion morphology,
abnormal pterygopalatine ganglion morphology,
abnormal sublingual ganglion morphology,
abnormal submandibular ganglion morphology,
abnormal trochlear nerve morphology,
decreased motor neuron number,
decreased pulmonary respiratory rate,
improved glucose tolerance,
increased insulin sensitivity,
increased neuron number,
increased pulmonary respiratory rate,
increased pulmonary ventilation,
increased tidal volume,
nervous system phenotype,
postnatal lethality, complete penetrance,
small geniculate ganglion,
small nodose ganglion,
small petrosal ganglion,
small submandibular ganglion,
small superior cervical ganglion,
small trigeminal ganglion
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.