Monarch Ortholog Phenotypes
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Human (35 sources):
Absence of renal corticomedullary differentiation,
Biliary tract abnormality,
Cholangitis,
Congenital hepatic fibrosis,
Dehydration,
Depressed nasal ridge,
Enlarged kidney,
Epigastric pain,
Esophageal varix,
Fever,
Hepatic cysts,
Hepatomegaly,
Hypertension,
Hypoplasia of the ear cartilage,
Liver abscess,
Low-set, posteriorly rotated ears,
Macrotia,
Micrognathia,
Multiple renal cysts,
Oligohydramnios,
Pancreatic cysts,
Periportal fibrosis,
Polycystic kidney dysplasia,
Portal hypertension,
Potter facies,
Pulmonary hypoplasia,
Recurrent fever,
Renal cyst,
Renal hypoplasia/aplasia,
Renal insufficiency,
Respiratory insufficiency,
Splenomegaly,
Tubulointerstitial fibrosis,
Vascular dilatation,
Vomiting
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Mouse (38 sources):
abnormal bile duct development,
abnormal bile duct morphology,
abnormal cholangiocyte primary cilium morphology,
abnormal extrahepatic bile duct morphology,
abnormal hepatic duct morphology,
abnormal hepatobiliary system morphology,
abnormal intrahepatic bile duct morphology,
abnormal kidney epithelium morphology,
abnormal kidney morphology,
abnormal liver development,
abnormal mitotic spindle morphology,
abnormal pancreatic duct morphology,
abnormal papillary duct morphology,
abnormal proximal convoluted tubule morphology,
abnormal renal tubule epithelial cell primary cilium morphology,
cellular phenotype,
decreased glomerular capillary number,
decreased kidney cell proliferation,
dilated bile duct,
dilated pancreatic duct,
dilated proximal convoluted tubule,
dilated renal tubules,
endocrine/exocrine gland phenotype,
increased glomerular capsule space,
increased kidney weight,
increased liver weight,
increased mesangial cell number,
increased renal tubule apoptosis,
neonatal lethality, incomplete penetrance,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
premature death,
prenatal lethality, incomplete penetrance,
proximal convoluted tubule brush border loss,
renal glomerulus cyst,
renal necrosis,
renal/urinary system phenotype,
reproductive system phenotype
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View all ortholog results at Monarch
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