tcf7 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-855461

Gene Symbol: tcf7 Gene Name: transcription factor 7

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the tail (4 sources), decreased length of anterior-posterior axis (3 sources), increased size of the head (3 sources), abnormal dorsal trunk morphology (2 sources), abnormally dorsalized embryo (2 sources), abnormal anterior-posterior axis, curved ventral (1 source), abnormal bending of anterior-posterior axis (1 source), arrested developmental process (1 source), decreased size of the head (1 source), wholly anterioralized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

decreased size of the tail (4 sources), decreased length of anterior-posterior axis (3 sources), increased size of the head (3 sources), abnormal dorsal trunk morphology (2 sources), abnormally dorsalized embryo (2 sources), abnormal anterior-posterior axis, curved ventral (1 source), abnormal bending of anterior-posterior axis (1 source), arrested developmental process (1 source), decreased size of the head (1 source), wholly anterioralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tcf7 manipulated (8 sources)
Computed annotations: tcf7 assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tcf7 MO (9 sources), Xla Wt + tcf7l1 MO (8 sources), Xla Wt + tcf7 MO (2 sources), Xla Wt + tcf7l1 MO (2 sources), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + tcf7 (1 source), Xla Wt + tcf7l1 (1 source), Xla Wt + tcf7l1 + jmjd6 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1del_970-1653-myc (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + tcf7 MO (9 sources), Xla Wt + tcf7l1 MO (8 sources), Xla Wt + tcf7 MO (2 sources), Xla Wt + tcf7l1 MO (2 sources), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + tcf7 (1 source), Xla Wt + tcf7l1 (1 source), Xla Wt + tcf7l1 + jmjd6 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1del_970-1653-myc (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (12 sources): abnormal T cell differentiation, abnormal forelimb morphology, abnormal memory T cell physiology, abnormal response to tactile stimuli, decreased CD4-positive, alpha beta T cell number, decreased double-positive T cell number, decreased single-positive T cell number, increased circulating alkaline phosphatase level, increased intestinal adenoma incidence, increased mammary adenoacanthoma incidence, increased osteoclast cell number, thymus cortex hypoplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (12 sources): abnormal T cell differentiation, abnormal forelimb morphology, abnormal memory T cell physiology, abnormal response to tactile stimuli, decreased CD4-positive, alpha beta T cell number, decreased double-positive T cell number, decreased single-positive T cell number, increased circulating alkaline phosphatase level, increased intestinal adenoma incidence, increased mammary adenoacanthoma incidence, [+]