trio Phenotypes

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Phenotypes

Gene Literature (5)

Nucleotides (220)

Interactants (40)

XB-GENEPAGE-922515

Gene Symbol: trio Gene Name: trio Rho guanine nucleotide exchange factor

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent filopodium (2 sources), decreased cell migration in branchial crest (2 sources), decreased cell migration in cranial neural crest (2 sources), decreased cell migration in hyoid crest (2 sources), decreased cell migration in mandibular crest (2 sources), decreased size of the Meckel's cartilage (1 source), decreased size of the chondrocranium (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: trio assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + trio MO (2 sources), Xla Wt + trio MO (1 source), Xla Wt + trio MO + neural crest explant (1 source), Xla Wt + trio MO + neural crest explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (68 sources): 2-3 toe syndactyly, Abnormality of the dentition, Abnormality of the hand, Absent speech, Aggressive behavior, Amblyopia, Aplasia of the 1st metacarpal, Attention deficit hyperactivity disorder, Autistic behavior, Behavioral abnormality, Brachydactyly, Chronic constipation, Clinodactyly, Clinodactyly of the 5th finger, Complete atrioventricular canal defect, Compulsive behaviors, Congenital ptosis, Delayed speech and language development, Dental crowding, Downslanted palpebral fissures, Epicanthus, Eruption failure, Facial asymmetry, Failure to thrive, Feeding difficulties, Feeding difficulties in infancy, Gait ataxia, Gastrostomy tube feeding in infancy, Global developmental delay, High forehead, High palate, Hypercalcemia, Hypodontia, Intellectual disability, Intellectual disability, borderline, Intellectual disability, mild, Kyphosis, Long philtrum, Macrotia, Microcephaly, Micrognathia, Motor delay, Motor stereotypy, Partial absence of thumb, Pectus excavatum, Pes planus, Poor speech, Poor suck, Primary microcephaly, Recurrent infections, Scoliosis, Secondary microcephaly, Seizure, Self-mutilation, Short nose, Short palm, Slanting of the palpebral fissure, Sleep disturbance, Specific learning disability, Strabismus, Synophrys, Tapered finger, Thick eyebrow, Thick vermilion border, Tremor, Unilateral radial aplasia, Upslanted palpebral fissure, Urinary incontinence [+]
Mouse (24 sources): abnormal Bergmann glial cell morphology, abnormal cerebellar granule cell migration, abnormal cerebellar granule cell morphology, abnormal cerebellar granule layer morphology, abnormal cerebellum external granule cell layer morphology, abnormal cerebellum lobule morphology, abnormal dentate gyrus morphology, abnormal myogenesis, abnormal neuron differentiation, abnormal olfactory bulb mitral cell layer morphology, abnormal rostral migratory stream morphology, abnormal skeletal muscle morphology, absent gastric milk in neonates, behavior/neurological phenotype, decreased brain size, increased neuron apoptosis, lethality throughout fetal growth and development, incomplete penetrance, limb grasping, neonatal lethality, incomplete penetrance, nervous system phenotype, perinatal lethality, complete penetrance, postnatal lethality, complete penetrance, small cerebellum, small olfactory bulb [+]
View all ortholog results at Monarch