Monarch Ortholog Phenotypes
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Human (50 sources):
Abnormal lower motor neuron morphology,
Abnormal pyramidal sign,
Abnormal upper motor neuron morphology,
Abnormality of eye movement,
Abnormality of the bladder,
Abnormality of the face,
Abnormality of the orbital region,
Achilles tendon contracture,
Amyotrophic lateral sclerosis,
Anarthria,
Babinski sign,
Cerebral cortical atrophy,
Decreased muscle mass,
Difficulty in tongue movements,
Distal amyotrophy,
Drooling,
Dysarthria,
Dysphagia,
Dystonia,
EMG abnormality,
EMG: chronic denervation signs,
Gait disturbance,
Gait imbalance,
Hand muscle atrophy,
Hyperreflexia,
Impaired mastication,
Loss of speech,
Lower limb spasticity,
Morphological abnormality of the pyramidal tract,
Motor delay,
Muscle weakness,
Pallor,
Pes cavus,
Pseudobulbar affect,
Saccadic smooth pursuit,
Scoliosis,
Sensory neuropathy,
Skeletal muscle atrophy,
Slow saccadic eye movements,
Spastic dysarthria,
Spastic gait,
Spastic paraplegia,
Spastic tetraparesis,
Spastic tetraplegia,
Spasticity,
Spasticity of facial muscles,
Spasticity of pharyngeal muscles,
Tetraplegia,
Upper limb spasticity,
Urinary incontinence
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Mouse (21 sources):
CNS inflammation,
abnormal Purkinje cell morphology,
abnormal action potential,
abnormal axon morphology,
abnormal axonal transport,
abnormal motor learning,
abnormal motor neuron innervation pattern,
abnormal neuromuscular synapse morphology,
abnormal physical strength,
abnormal skeletal muscle fiber type ratio,
abnormal ventral spinal root morphology,
behavior/neurological phenotype,
decreased Purkinje cell number,
decreased exploration in new environment,
decreased locomotor activity,
decreased motor neuron number,
increased anxiety-related response,
increased physiological sensitivity to xenobiotic,
increased sensitivity to xenobiotic induced morbidity/mortality,
nervous system phenotype,
skeletal muscle fiber atrophy
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View all ortholog results at Monarch
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