| Monarch Ortholog Phenotypes
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Human (39 sources):
Abnormal fingernail morphology,
Abnormality of the dentition,
Abnormality of the nail,
Abnormality of the skin,
Arachnodactyly,
Atrophy of alveolar ridges,
Cerebral calcification,
Choroid plexus calcification,
Chronic furunculosis,
Cigarette-paper scars,
Congenital palmoplantar hyperkeratosis,
Generalized hirsutism,
Gingival recession,
Gingivitis,
Hypertrichosis,
Hypopigmented skin patches,
Liver abscess,
Melanoma,
Nail dystrophy,
Neoplasm of the skin,
Onychogryposis,
Osteolysis,
Osteolytic defects of the phalanges of the hand,
Palmoplantar hyperkeratosis,
Palmoplantar keratoderma,
Periodontitis,
Pes planus,
Premature loss of primary teeth,
Premature loss of teeth,
Pustule,
Recurrent bacterial skin infections,
Recurrent cutaneous abscess formation,
Recurrent respiratory infections,
Recurrent skin infections,
Severe periodontitis,
Sparse body hair,
Squamous cell carcinoma,
Tapering pointed ends of distal finger phalanges,
Tooth agenesis
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Mouse (10 sources):
abnormal chemokine level,
abnormal cytotoxic T cell physiology,
abnormal leukocyte migration,
abnormal response to infection,
decreased circulating interleukin-6 level,
decreased prepulse inhibition,
disheveled coat,
impaired neutrophil recruitment,
increased circulating interleukin-6 level,
increased thermal nociceptive threshold
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.