abnormal epidermal pigmentation, abnormal hematopoietic stem cell morphology, abnormal hematopoietic stem cell physiology, abnormal hepatocyte morphology, abnormal intestinal goblet cell morphology, abnormal kidney morphology, abnormal locomotor behavior, abnormal macrophage physiology, abnormal mammary gland morphology, abnormal melanocyte proliferation, abnormal melanosome morphology, abnormal renal glomerulus morphology, abnormal response to social novelty, abnormal sensory neuron morphology, abnormal social investigation, abnormal substantia nigra pars compacta morphology, absent cerebral cortex pyramidal cells, absent hippocampus pyramidal cells, behavior/neurological phenotype, cellular phenotype, curly tail, decreased bone marrow cell number, decreased circulating alanine transaminase level, decreased circulating interleukin-10 level, decreased common myeloid progenitor cell number, decreased dopamine level, decreased foot pigmentation, decreased hematopoietic stem cell number, decreased survivor rate, decreased tail pigmentation, dilated mitochondria, early cellular replicative senescence, impaired autophagy, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased autoantibody level, increased circulating alanine transaminase level, increased circulating alkaline phosphatase level, increased circulating aspartate transaminase level, increased circulating creatinine level, increased circulating interleukin-1 beta level, increased circulating interleukin-12b level, increased circulating interleukin-6 level, increased hepatocyte proliferation, increased liver weight, increased neuron apoptosis, increased neutrophil cell number, increased susceptibility to systemic lupus erythematosus, limb grasping, neonatal lethality, complete penetrance, nervous system phenotype, neuron degeneration, oxidative stress, premature death, preweaning lethality, complete penetrance