| Monarch Ortholog Phenotypes
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Human (14 sources):
Autism,
Bilateral tonic-clonic seizure,
Delayed ability to walk,
Delayed speech and language development,
EEG abnormality,
Generalized hypotonia,
Global developmental delay,
Impaired social interactions,
Inability to walk,
Joint laxity,
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Mouse (34 sources):
abnormal amygdala morphology,
abnormal blood urea nitrogen level,
abnormal brain interneuron morphology,
abnormal circulating total protein level,
abnormal conditioned taste aversion behavior,
abnormal cued conditioning behavior,
abnormal erythrocyte cell number,
abnormal excitatory postsynaptic currents,
abnormal habituation to a new environment,
abnormal innervation,
abnormal miniature inhibitory postsynaptic currents,
abnormal mitral cell morphology,
abnormal neuron physiology,
abnormal olfactory bulb development,
abnormal olfactory bulb external plexiform layer morphology,
abnormal olfactory bulb glomerular layer morphology,
abnormal olfactory bulb interneuron morphology,
abnormal olfactory bulb mitral cell layer morphology,
abnormal olfactory bulb tufted cell morphology,
abnormal olfactory cortex morphology,
abnormal olfactory tract morphology,
abnormal prepulse inhibition,
abnormal social investigation,
aphagia,
cognitive inflexibility,
decreased brain size,
decreased thigmotaxis,
decreased vocalization,
impaired social transmission of food preference,
increased anxiety-related response,
increased grooming behavior,
increased vertical activity,
postnatal lethality, complete penetrance,
preweaning lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.