| Monarch Ortholog Phenotypes
|
Human (36 sources):
Abnormal thorax morphology,
Abnormality of the nervous system,
Basilar impression,
Beaking of vertebral bodies,
Biconcave flattened vertebrae,
Biconcave vertebral bodies,
Blue sclerae,
Bowing of limbs due to multiple fractures,
Coxa vara,
Decreased calvarial ossification,
Dentinogenesis imperfecta,
Disproportionate short-limb short stature,
Femoral bowing present at birth, straightening with time,
Frontal bossing,
Hearing impairment,
Increased susceptibility to fractures,
Kyphosis,
Micrognathia,
Multiple prenatal fractures,
Neonatal short-limb short stature,
Otosclerosis,
Platybasia,
Protrusio acetabuli,
Pulmonary arterial hypertension,
Recurrent fractures,
Reduced bone mineral density,
Scoliosis,
Severe generalized osteoporosis,
Short stature,
Slender long bone,
Tibial bowing,
Triangular face,
Vertebral compression fracture,
Wide anterior fontanel,
Wormian bones,
obsolete Joint laxity
[+]
|
|
Mouse (18 sources):
abnormal angiogenesis,
abnormal bone mineralization,
abnormal exocrine pancreas morphology,
abnormal mean corpuscular hemoglobin concentration,
abnormal pancreatic acinar cell morphology,
abnormal prostate gland morphology,
abnormal retina vasculature morphology,
decreased bone strength,
decreased bone trabecula number,
decreased mean corpuscular hemoglobin concentration,
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.