hif1a Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-946621

Gene Symbol: hif1a Gene Name: hypoxia inducible factor 1 subunit alpha

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal regenerating tail (2 sources), decreased length of regenerating tail (2 sources), abnormal Wnt signaling pathway (1 source), abnormal cranial neural crest morphology (1 source), abnormal neural plate morphology (1 source), decreased cell migration in branchial crest (1 source), decreased cell migration in cranial neural crest (1 source), decreased cell migration in hyoid crest (1 source), decreased cell migration in mandibular crest (1 source), decreased size of the main body axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal regenerating tail (2 sources), decreased length of regenerating tail (2 sources), abnormal Wnt signaling pathway (1 source), abnormal cranial neural crest morphology (1 source), abnormal neural plate morphology (1 source), decreased cell migration in branchial crest (1 source), decreased cell migration in cranial neural crest (1 source), decreased cell migration in hyoid crest (1 source), decreased cell migration in mandibular crest (1 source), decreased size of the main body axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hif1a manipulated (1 source)
Computed annotations: hif1a assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + hif1a MO NF1 (2 sources), Xtr Wt + hif1a MO NF2 (1 source), Xtr Wt + hif1a vMO 20ng + posterior tail amputation (1 source), Xtr.Tg(pbin7:GFP) + hif1a MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (140 sources): abnormal T cell differentiation, abnormal angiogenesis, abnormal body temperature, abnormal brain vasculature morphology, abnormal cardiac muscle relaxation, abnormal cardiac outflow tract development, abnormal cartilage development, abnormal cerebral cortex morphology, abnormal cerebral hemisphere morphology, abnormal coronary vessel morphology, abnormal cortical plate morphology, abnormal cytokine level, abnormal dendritic cell number, abnormal developmental patterning, abnormal dorsal aorta morphology, abnormal embryo development, abnormal embryonic epiblast morphology, abnormal exercise endurance, abnormal gluconeogenesis, abnormal head mesenchyme morphology, abnormal heart development, abnormal heart left ventricle pressure, abnormal heart looping, abnormal heart size, abnormal heart tube morphology, abnormal hematopoietic stem cell physiology, abnormal innervation pattern to muscle, abnormal interleukin-1 beta secretion, abnormal intersomitic vessel morphology, abnormal lactation, abnormal lens fiber morphology, abnormal leukocyte migration, abnormal leukocyte physiology, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal macrophage physiology, abnormal mammary gland alveolus morphology, abnormal mammary gland epithelium morphology, abnormal mammary gland morphology, abnormal milk composition, abnormal milk sodium level, abnormal myocardial fiber physiology, abnormal myocardium layer morphology, abnormal neural crest cell migration, abnormal neural fold formation, abnormal occipital lobe morphology, abnormal pericardial cavity morphology, abnormal pericardium morphology, abnormal physiological response to xenobiotic, abnormal pulmonary alveolus epithelial cell morphology, abnormal pulmonary alveolus morphology, abnormal somite development, abnormal spatial learning, abnormal sternocostal joint morphology, abnormal sternum morphology, abnormal surfactant secretion, abnormal systemic arterial blood pressure, abnormal temporal lobe morphology, abnormal thoracic cage shape, abnormal tracheal cartilage morphology, abnormal tracheal ciliated epithelium morphology, abnormal type II pneumocyte morphology, abnormal vascular development, abnormal vascular endothelial cell migration, abnormal vascular regression, abnormal vitelline vascular remodeling, absent myocardial trabeculae, absent pharyngeal arch arteries, absent second pharyngeal arch, absent third pharyngeal arch, behavior/neurological phenotype, cardia bifida, cardiac hypertrophy, cardiovascular system phenotype, decreased angiogenesis, decreased cardiac muscle contractility, decreased cell proliferation, decreased circulating glucose level, decreased common myeloid progenitor cell number, decreased embryo size, decreased hepatocyte proliferation, decreased interleukin-1 alpha secretion, decreased interleukin-1 beta secretion, decreased interleukin-12 secretion, decreased interleukin-6 secretion, decreased liver glycogen level, decreased neuron apoptosis, decreased sensitivity to xenobiotic induced morbidity/mortality, decreased susceptibility to endotoxin shock, decreased susceptibility to induced arthritis, decreased susceptibility to ischemic brain injury, decreased tumor growth/size, decreased tumor necrosis factor secretion, decreased vascular endothelial cell proliferation, delayed wound healing, dilated dorsal aorta, disorganized long bone epiphyseal plate, disorganized myocardium, disorganized yolk sac vascular plexus, early cellular replicative senescence, embryonic growth arrest, embryonic growth retardation, embryonic lethality between implantation and somite formation, incomplete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, enlarged lateral ventricles, hypoxia, immune system phenotype, impaired liver regeneration, impaired macrophage chemotaxis, incomplete somite formation, increased apoptosis, increased cellular sensitivity to gamma-irradiation, increased cerebral infarct size, increased embryonic tissue cell apoptosis, increased hematopoietic stem cell number, increased hindbrain size, increased interferon-gamma secretion, increased left ventricle weight, increased lens fiber apoptosis, increased long bone epiphyseal plate size, increased lung weight, increased sensitivity to induced morbidity/mortality, increased susceptibility to induced colitis, increased susceptibility to injury, increased susceptibility to ischemic brain injury, increased tumor necrosis factor secretion, loss of cortex neurons, loss of hippocampal neurons, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, open neural tube, pharyngeal arch artery hypoplasia, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, small second pharyngeal arch, thick interventricular septum, thick pulmonary interalveolar septum, thick ventricular wall [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (140 sources): abnormal T cell differentiation, abnormal angiogenesis, abnormal body temperature, abnormal brain vasculature morphology, abnormal cardiac muscle relaxation, abnormal cardiac outflow tract development, abnormal cartilage development, abnormal cerebral cortex morphology, abnormal cerebral hemisphere morphology, abnormal coronary vessel morphology, [+]