itgb1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-946724

Gene Symbol: itgb1 Gene Name: integrin subunit beta 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal head morphology (2 sources), abnormal tail bud morphology (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal convergent extension involved in axis elongation (1 source), abnormal gastrulation (1 source), abnormal incomplete closing of the neural tube (1 source), abnormal neural tube closure (1 source), abnormally decreased mobility of non-neural ectoderm (1 source), abnormally delayed closure of blastopore (1 source), wholly ventralized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal head morphology (2 sources), abnormal tail bud morphology (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal convergent extension involved in axis elongation (1 source), abnormal gastrulation (1 source), abnormal incomplete closing of the neural tube (1 source), abnormal neural tube closure (1 source), abnormally decreased mobility of non-neural ectoderm (1 source), abnormally delayed closure of blastopore (1 source), wholly ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: itgb1 assayed (3 sources)
Computed annotations: itgb1 assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + itgb1 MO (3 sources), Xla Wt + itgb1 MO (2 sources), Xla Wt + itgb1 MO + non-neural ectoderm ablation (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (188 sources): abnormal CNS glial cell morphology, abnormal Cajal-Retzius cell morphology, abnormal atrial thrombosis, abnormal basement membrane morphology, abnormal blastocoele morphology, abnormal bone mineralization, abnormal cardiac cell glucose uptake, abnormal cardiac mesenchyme morphology, abnormal cardiac muscle relaxation, abnormal cartilage development, abnormal cell adhesion, abnormal cerebellar foliation, abnormal cerebellum development, abnormal cerebellum vermis morphology, abnormal cerebral cortex morphology, abnormal chondrocyte morphology, abnormal choroid plexus morphology, abnormal circulating lipid level, abnormal cortical marginal zone morphology, abnormal craniofacial morphology, abnormal crypts of Lieberkuhn morphology, abnormal dermal layer morphology, abnormal dermal pigmentation, abnormal digit development, abnormal ear position, abnormal embryo development, abnormal embryo implantation, abnormal enteric neural crest cell migration, abnormal enteric neural crest cell morphology, abnormal enteric neuron morphology, abnormal enterocyte morphology, abnormal epidermal-dermal junction morphology, abnormal epidermis stratum basale morphology, abnormal esophageal epithelium morphology, abnormal eye distance/ position, abnormal first pharyngeal arch morphology, abnormal glomerular capillary morphology, abnormal hair follicle development, abnormal hair follicle morphology, abnormal hair follicle outer root sheath morphology, abnormal inner cell mass morphology, abnormal innervation, abnormal innervation pattern to muscle, abnormal intestinal absorption, abnormal intestinal epithelium morphology, abnormal keratinocyte morphology, abnormal kidney collecting duct morphology, abnormal kidney morphology, abnormal left-right axis patterning, abnormal lens epithelium morphology, abnormal lens fiber morphology, abnormal limb morphology, abnormal long bone epiphyseal plate morphology, abnormal long bone hypertrophic chondrocyte zone, abnormal mammary gland growth during lactation, abnormal mammary gland morphology, abnormal meninges morphology, abnormal myocardial fiber morphology, abnormal myocardium layer morphology, abnormal myogenesis, abnormal myotube morphology, abnormal neuromuscular synapse morphology, abnormal neuronal precursor cell migration, abnormal placenta labyrinth morphology, abnormal placenta morphology, abnormal placental labyrinth vasculature morphology, abnormal radial glial cell morphology, abnormal renal filtration rate, abnormal renal glomerular capsule morphology, abnormal renal glomerulus basement membrane morphology, abnormal renal glomerulus morphology, abnormal renal transport, abnormal renal tubule epithelium morphology, abnormal rostral migratory stream morphology, abnormal sciatic nerve morphology, abnormal skeletal muscle morphology, abnormal skin condition, abnormal spine curvature, abnormal trophoblast layer morphology, abnormal visceral endoderm morphology, absent Schwann cell precursors, absent blastocoele, absent inner cell mass, absent sebaceous gland, aphakia, cardiac fibrosis, cardiovascular system phenotype, chondrodystrophy, decreased body length, decreased body size, decreased cell proliferation, decreased chondrocyte number, decreased chondrocyte proliferation, decreased circulating bicarbonate level, decreased circulating noradrenaline level, decreased embryo size, decreased fetal size, decreased fibroblast cell migration, decreased fibroblast proliferation, decreased hair follicle cell proliferation, decreased hair follicle number, decreased hematocrit, decreased hindbrain size, decreased incidence of tumors by chemical induction, decreased keratinocyte adhesion, decreased keratinocyte migration, decreased keratinocyte proliferation, decreased kidney weight, decreased locomotor activity, decreased platelet calcium level, decreased skeletal muscle fiber number, decreased skeletal muscle mass, decreased urine osmolality, decreased ventricle muscle contractility, delayed somite formation, delayed wound healing, dermal-epidermal separation, dilated glomerular capillary, dilated heart, dilated heart left ventricle, dilated kidney collecting duct, dilated renal tubules, disorganized pancreatic islets, disproportionate dwarf, embryonic growth arrest, embryonic growth retardation, embryonic lethality before implantation, complete penetrance, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, complete penetrance, embryonic lethality, incomplete penetrance, endocrine/exocrine gland phenotype, enlarged hair follicles, enlarged heart atrium, epidermal hyperplasia, failure of chorioallantoic fusion, hearing/vestibular/ear phenotype, impaired skin barrier function, increased apoptosis, increased chondrocyte apoptosis, increased diameter of long bones, increased embryonic neuroepithelium thickness, increased kidney apoptosis, increased kidney cell proliferation, increased mesangial cell number, increased pancreatic alpha cell number, increased podocyte apoptosis, increased response of heart to induced stress, increased sensitivity to induced morbidity/mortality, increased urine pH, inner cell mass degeneration, integument phenotype, kidney medulla cyst, kidney medulla hypoplasia, kinked neural tube, lethality throughout fetal growth and development, complete penetrance, lethality, complete penetrance, liver vascular congestion, mandible hypoplasia, muscle phenotype, muscular atrophy, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, nervous system phenotype, no abnormal phenotype detected, open neural tube, pale kidney, perianal ulcer, perinatal lethality, incomplete penetrance, podocyte foot process effacement, postnatal lethality, complete penetrance, premature death, preweaning lethality, complete penetrance, preweaning lethality, incomplete penetrance, progressive hair loss, radial glial endfoot detachment, renal cast, reproductive system phenotype, skin lesions, small cerebellum, small first pharyngeal arch, small kidney, small olfactory bulb, small second pharyngeal arch, thick ventricular wall, thin epidermis, wavy neural tube [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (188 sources): abnormal CNS glial cell morphology, abnormal Cajal-Retzius cell morphology, abnormal atrial thrombosis, abnormal basement membrane morphology, abnormal blastocoele morphology, abnormal bone mineralization, abnormal cardiac cell glucose uptake, abnormal cardiac mesenchyme morphology, abnormal cardiac muscle relaxation, abnormal cartilage development, [+]