| Monarch Ortholog Phenotypes
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Human (49 sources):
Acute infectious pneumonia,
Arrhythmia,
Bronchiectasis,
Cachexia,
Cerebral ischemia,
Chest pain,
Chronic bronchitis,
Cleft palate,
Clubbing,
Constipation,
Crackles,
Decreased circulating renin level,
Decreased pulmonary function,
Dehydration,
Diarrhea,
Dyspnea,
Elevated sweat chloride,
Emphysema,
Failure to thrive,
Fatigue,
Feeding difficulties in infancy,
Fever,
Halitosis,
Hemoptysis,
Hyperactive renin-angiotensin system,
Hyperaldosteronism,
Hyperkalemia,
Hypertension,
Hypokalemia,
Hypokalemic alkalosis,
Hyponatremia,
Hypotension,
Metabolic acidosis,
Metabolic alkalosis,
Muscle weakness,
Myocardial infarction,
Nephropathy,
Productive cough,
Pseudohypoaldosteronism,
Recurrent Haemophilus influenzae infections,
Recurrent lower respiratory tract infections,
Recurrent respiratory infections,
Reduced FEV1/FVC ratio,
Renal insufficiency,
Renal salt wasting,
Respiratory tract infection,
Vomiting,
Wheezing,
obsolete Decreased circulating aldosterone level
[+]
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Mouse (16 sources):
abnormal kidney morphology,
abnormal mucociliary clearance,
abnormal respiratory mucosa goblet cell morphology,
bronchitis,
cardiac hypertrophy,
increased systemic arterial systolic blood pressure,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
postnatal lethality,
postnatal lethality, complete penetrance,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.