scnn1b Phenotypes

XB-GENEPAGE-949108

Gene Symbol: scnn1b Gene Name: sodium channel, non voltage gated 1 beta subunit

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (49 sources): Acute infectious pneumonia, Arrhythmia, Bronchiectasis, Cachexia, Cerebral ischemia, Chest pain, Chronic bronchitis, Cleft palate, Clubbing, Constipation, Crackles, Decreased circulating renin concentration, Dehydration, Diarrhea, Dyspnea, Elevated sweat chloride, Emphysema, Failure to thrive, Fatigue, Feeding difficulties in infancy, Fever, Halitosis, Hemoptysis, Hyperactive renin-angiotensin system, Hyperkalemia, Hypertension, Hypokalemia, Hypokalemic alkalosis, Hyponatremia, Hypotension, Increased circulating aldosterone concentration, Metabolic acidosis, Metabolic alkalosis, Muscle weakness, Myocardial infarction, Nephropathy, obsolete Decreased circulating aldosterone level, obsolete Decreased pulmonary function, Productive cough, Pseudohypoaldosteronism, Recurrent Haemophilus influenzae infections, Recurrent lower respiratory tract infections, Recurrent respiratory infections, Reduced FEV1/FVC ratio, Renal insufficiency, Renal salt wasting, Respiratory tract infection, Vomiting, Wheezing [+]
Mouse (16 sources): abnormal kidney morphology, abnormal mucociliary clearance, abnormal respiratory mucosa goblet cell morphology, bronchitis, cardiac hypertrophy, increased systemic arterial systolic blood pressure, neonatal lethality, complete penetrance, no abnormal phenotype detected, postnatal lethality, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, pulmonary epithelial necrosis, respiratory system inflammation, respiratory system phenotype, salt-sensitive hypertension [+]
View all ortholog results at Monarch