arhgef6 Phenotypes

XB-GENEPAGE-949772

Gene Symbol: arhgef6 Gene Name: Rac/Cdc42 guanine nucleotide exchange factor 6

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (37 sources): 2-3 toe syndactyly, Attention deficit hyperactivity disorder, Autistic behavior, Babinski sign, Bilateral tonic-clonic seizure, Broad nasal tip, Clinodactyly of the 2nd toe, Delayed eruption of teeth, Delayed speech and language development, Depressed nasal bridge, Downslanted palpebral fissures, Drooling, Facial palsy, Generalized non-motor (absence) seizure, Global developmental delay, Intellectual disability, moderate, Intellectual disability, profound, Intellectual disability, severe, Long palpebral fissure, Long philtrum, Macrocephaly, Meckel diverticulum, Midface retrusion, Mild neurosensory hearing impairment, Moderate sensorineural hearing impairment, Obesity, Periorbital fullness, Pes planus, Poor speech, Pyloric stenosis, Seizure, Shortening of all distal phalanges of the fingers, Small for gestational age, Thick lower lip vermilion, Thin upper lip vermilion, Urinary incontinence, Widened subarachnoid space [+]
Mouse (16 sources): abnormal dendrite morphology, abnormal dendritic spine morphology, abnormal humoral immune response, abnormal long term depression, abnormal response to novel object, abnormal spatial learning, abnormal synapse morphology, behavior/neurological phenotype, decreased B cell proliferation, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased interleukin-2 secretion, decreased mature B cell number, enlarged lymph nodes, increased heart weight, reduced long term potentiation [+]
View all ortholog results at Monarch