Monarch Ortholog Phenotypes
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Human (9 sources):
Agammaglobulinemia,
Chronic diarrhea,
Decreased circulating antibody level,
Failure to thrive,
Immunodeficiency,
Otitis media,
Recurrent fungal infections,
Respiratory tract infection,
Sinusitis
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Mouse (55 sources):
abnormal B cell activation,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal T cell activation,
abnormal effector T cell number,
abnormal fibroblast migration,
abnormal hepatocyte morphology,
abnormal humoral immune response,
abnormal intestinal mucosa morphology,
abnormal myotube morphology,
abnormal response to infection,
abnormal response to injury,
abnormal splenic cell ratio,
decreased B cell apoptosis,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased CD4-positive, alpha beta T cell number,
decreased acute inflammation,
decreased central memory CD4-positive, alpha-beta T cell number,
decreased circulating tumor necrosis factor level,
decreased fibroblast cell migration,
decreased fibroblast chemotaxis,
decreased follicular B cell number,
decreased germinal center B cell number,
decreased immature B cell number,
decreased interleukin-6 secretion,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased memory B cell number,
decreased memory T cell number,
decreased regulatory T cell number,
decreased single-positive T cell number,
dissociated hepatocytes,
embryonic lethality during organogenesis, complete penetrance,
impaired macrophage chemotaxis,
impaired neutrophil recruitment,
increased B cell apoptosis,
increased B cell proliferation,
increased IgG1 level,
increased cell proliferation,
increased cellular sensitivity to gamma-irradiation,
increased enterocyte apoptosis,
increased fibroblast apoptosis,
increased hepatocyte apoptosis,
increased macrophage apoptosis,
increased plasma cell number,
increased regulatory T cell number,
increased response to antigen,
increased skeletal muscle fiber number,
lethality throughout fetal growth and development, complete penetrance,
liver hemorrhage,
liver/biliary system phenotype,
no abnormal phenotype detected,
prenatal lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
small liver
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View all ortholog results at Monarch
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