| Monarch Ortholog Phenotypes
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Human (20 sources):
Abnormality of the cardiovascular system,
Elevated circulating apolipoprotein A-II concentration,
Elevated circulating apolipoprotein B concentration,
Episodic abdominal pain,
Eruptive xanthomas,
Hepatosplenomegaly,
Hypercholesterolemia,
Hyperlipidemia,
Increased LDL cholesterol concentration,
Increased VLDL cholesterol concentration,
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Mouse (21 sources):
abnormal fatty acids level,
abnormal lipid homeostasis,
abnormal lipid level,
abnormal lung vasculature morphology,
abnormal pulmonary alveolus morphology,
abnormal skeletal muscle morphology,
cardiac fibrosis,
cardiac interstitial fibrosis,
decreased cardiac muscle contractility,
increased cardiac cell glucose uptake,
increased cholesterol level,
increased circulating VLDL triglyceride level,
increased circulating phospholipid level,
increased left ventricle diastolic pressure,
increased left ventricle systolic pressure,
increased sensitivity to induced morbidity/mortality,
increased total fat pad weight,
increased triglyceride level,
liver vascular congestion,
neonatal lethality, complete penetrance,
pulmonary vascular congestion
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.