| Monarch Ortholog Phenotypes
|
Human (34 sources):
Abnormal pyramidal sign,
Abnormality of retinal pigmentation,
Abnormality of visual evoked potentials,
Areflexia,
Arrhythmia,
Ataxia,
Developmental regression,
Diabetes mellitus,
Dysarthria,
Dysdiadochokinesis,
Dysmetria,
Dystonia,
Gait disturbance,
Hemiplegia/hemiparesis,
Hypercholesterolemia,
Hypertriglyceridemia,
Hypertrophic cardiomyopathy,
Increased LDL cholesterol concentration,
Low levels of vitamin E,
Mental deterioration,
Muscle weakness,
Neurological speech impairment,
Nyctalopia,
Nystagmus,
Peripheral neuropathy,
Pes cavus,
Scoliosis,
Sensory neuropathy,
Skeletal muscle atrophy,
Spasticity,
Tendon xanthomatosis,
Tremor,
Visual impairment,
Xanthelasma
[+]
|
|
Mouse (13 sources):
abnormal eye electrophysiology,
abnormal lipid homeostasis,
abnormal somatosensory cortex physiology,
abnormal spinal cord ventral horn morphology,
abnormal vitamin E level,
cardiovascular system phenotype,
decreased trophoblast giant cell number,
disorganized retina layers,
head shaking,
increased variability of skeletal muscle fiber size,
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.