| Monarch Ortholog Phenotypes
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Human (4 sources):
Bilateral tonic-clonic seizure with focal onset,
Focal aware seizure,
Focal impaired awareness seizure,
Focal sensory seizure with auditory features
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Mouse (27 sources):
abnormal CNS synaptic transmission,
abnormal axon pruning,
abnormal brain wave pattern,
abnormal cerebellar granule cell morphology,
abnormal cerebellum external granule cell layer morphology,
abnormal cerebral cortex morphology,
abnormal dendrite morphology,
abnormal glutamate-mediated receptor currents,
abnormal hippocampal mossy fiber morphology,
abnormal miniature excitatory postsynaptic currents,
abnormal neocortex morphology,
abnormal paired-pulse facilitation,
abnormal paired-pulse inhibition,
abnormal spike wave discharge,
abnormal synapse morphology,
aphagia,
audiogenic seizures,
clonic seizures,
decreased body size,
decreased excitatory postsynaptic current amplitude,
environmentally induced seizures,
increased excitatory postsynaptic current amplitude,
increased susceptibility to pharmacologically induced seizures,
nervous system phenotype,
postnatal lethality, complete penetrance,
premature death,
tonic seizures
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.