| Monarch Ortholog Phenotypes
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Human (1 source):
Acute myeloid leukemia
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Mouse (28 sources):
abnormal bone marrow cell morphology/development,
abnormal embryonic tissue morphology,
abnormal erythropoiesis,
abnormal fetal liver hematopoietic progenitor cell morphology,
abnormal hepatocyte physiology,
abnormal spleen B cell follicle morphology,
decreased CD4-positive, alpha beta T cell number,
decreased body size,
decreased bone marrow cell number,
decreased embryo size,
decreased embryo weight,
decreased erythroblast number,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased mean corpuscular hemoglobin,
decreased mean corpuscular volume,
diluted coat color,
fetal growth retardation,
hemosiderosis,
impaired hematopoiesis,
increased circulating erythropoietin level,
increased circulating iron level,
increased erythroblast number,
increased red blood cell distribution width,
lethality throughout fetal growth and development, complete penetrance,
lethality, complete penetrance,
postnatal lethality, incomplete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.