gria2 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (67)

XB-GENEPAGE-966065

Gene Symbol: gria2 Gene Name: glutamate receptor, ionotropic, AMPA 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: gria2 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (59 sources): abnormal AMPA-mediated synaptic currents, abnormal CNS glial cell morphology, abnormal amygdala morphology, abnormal brain interneuron morphology, abnormal circadian sleep/wake cycle, abnormal excitatory postsynaptic currents, abnormal excitatory postsynaptic potential, abnormal glutamate-mediated receptor currents, abnormal grooming behavior, abnormal hippocampus CA3 region morphology, abnormal learning/memory/conditioning, abnormal limb posture, abnormal long term spatial reference memory, abnormal mating frequency, abnormal motor capabilities/coordination/movement, abnormal neuron differentiation, abnormal nociception after inflammation, abnormal olfactory discrimination memory, abnormal paired-pulse facilitation, abnormal pup retrieval, abnormal response to novel object, abnormal sexual interaction, abnormal spatial learning, abnormal spatial reference memory, abnormal spatial working memory, abnormal spinal cord ventral horn morphology, abnormal startle reflex, abnormal touch/ nociception, abnormal ventromedial hypothalamic nucleus morphology, absent long term depression, behavior/neurological phenotype, decreased aggression towards male mice, decreased body size, decreased chemical nociceptive threshold, decreased exploration in new environment, decreased grip strength, decreased grooming behavior, decreased locomotor activity, decreased spinal cord ventral horn cell number, enhanced AMPA-mediated synaptic currents, enhanced long term potentiation, hearing/vestibular/ear phenotype, hippocampal neuron degeneration, hyperalgesia, impaired contextual conditioning behavior, impaired spatial learning, impaired synaptic plasticity, increased anxiety-related response, increased exploration in new environment, increased susceptibility to neuronal excitotoxicity, jumpy, loss of hippocampal neurons, nervous system phenotype, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, premature death, preweaning lethality, complete penetrance, reproductive system phenotype, short stride length [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (59 sources): abnormal AMPA-mediated synaptic currents, abnormal CNS glial cell morphology, abnormal amygdala morphology, abnormal brain interneuron morphology, abnormal circadian sleep/wake cycle, abnormal excitatory postsynaptic currents, abnormal excitatory postsynaptic potential, abnormal glutamate-mediated receptor currents, abnormal grooming behavior, abnormal hippocampus CA3 region morphology, [+]