dlg5 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-978274

Gene Symbol: dlg5 Gene Name: discs large homolog 5

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the proximal tubule (3 sources), abnormal kidney morphology (2 sources), abnormally decreased number of cilium in the pronephric kidney (2 sources), abnormal brain ventricle morphology (1 source), abnormal establishment of apical/basal cell polarity (1 source), abnormally decreased number of multiciliated epidermal cell (1 source), abnormally increased number of goblet cell (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased size of the proximal tubule (3 sources), abnormal kidney morphology (2 sources), abnormally decreased number of cilium in the pronephric kidney (2 sources), abnormal brain ventricle morphology (1 source), abnormal establishment of apical/basal cell polarity (1 source), abnormally decreased number of multiciliated epidermal cell (1 source), abnormally increased number of goblet cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dlg5 manipulated (3 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
ciliopathy (4AP sources, 2 EP sources), communicating hydrocephalus (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + dlg5 MO (9 sources), Xtr Wt + dlg5 CRISPR (2 sources), Xtr Wt + Hsa.DLG5Arg249Trp (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (12 sources): abnormal cerebral aqueduct morphology, abnormal ependyma morphology, abnormal kidney collecting duct morphology, abnormal neuron differentiation, abnormal papillary duct morphology, abnormal postnatal subventricular zone morphology, abnormal renal tubule morphology, abnormal third ventricle morphology, dilated kidney collecting duct, increased brain size, preweaning lethality, complete penetrance, ureter stenosis [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (12 sources): abnormal cerebral aqueduct morphology, abnormal ependyma morphology, abnormal kidney collecting duct morphology, abnormal neuron differentiation, abnormal papillary duct morphology, abnormal postnatal subventricular zone morphology, abnormal renal tubule morphology, abnormal third ventricle morphology, dilated kidney collecting duct, increased brain size, [+]