ddc Phenotypes

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Phenotypes

Gene Literature (14)

Nucleotides (109)

Interactants (72)

XB-GENEPAGE-983284

Gene Symbol: ddc Gene Name: dopa decarboxylase

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ddc assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (24 sources): Abnormality of the face, Axial hypotonia, Babinski sign, Choreoathetosis, Constipation, Decreased CSF homovanillic acid concentration, Diarrhea, Emotional lability, Feeding difficulties in infancy, Gastroesophageal reflux, Global developmental delay, Hyperhidrosis, Hyperreflexia, Hypotension, Intermittent hypothermia, Irritability, Limb dystonia, Limb hypertonia, Miosis, Myoclonus, Nasal congestion, Ptosis, Sleep disturbance, Temperature instability [+]
Mouse (37 sources): abnormal dopamine level, abnormal embryo development, abnormal embryonic tissue morphology, abnormal locomotor activation, abnormal maternal nurturing, abnormal motor learning, abnormal noradrenaline level, abnormal response/metabolism to endogenous compounds, abnormal synaptic neurotransmitter level, decreased body size, decreased dopamine level, decreased embryo size, decreased locomotor activity, decreased renin activity, decreased serotonin level, decreased systemic arterial systolic blood pressure, delayed eyelid opening, embryonic lethality, complete penetrance, impaired adaptive thermogenesis, increased anxiety-related response, increased circulating creatinine level, increased heart weight, increased kidney weight, increased mean systemic arterial blood pressure, increased renin activity, increased systemic arterial systolic blood pressure, increased thigmotaxis, increased vertical activity, induced hyperactivity, lethality throughout fetal growth and development, incomplete penetrance, limb grasping, oxidative stress, premature death, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, reduced female fertility, salt-sensitive hypertension [+]
View all ortholog results at Monarch