atf4 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-983840

Gene Symbol: atf4 Gene Name: activating transcription factor 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: atf4 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (48 sources): abnormal bone mineralization, abnormal calcium ion homeostasis, abnormal clavicle morphology, abnormal embryo size, abnormal frontal bone morphology, abnormal glycogen homeostasis, abnormal lens fiber morphology, abnormal mean corpuscular hemoglobin, abnormal mean corpuscular volume, abnormal neurocranium morphology, abnormal osteoblast differentiation, abnormal pancreatic acinar cell morphology, abnormal pancreatic acinar cell zymogen granule morphology, abnormal pancreatic acinus morphology, absent common myeloid progenitor cells, aphakia, decreased body length, decreased body size, decreased cell proliferation, decreased circulating glucose level, decreased fetal size, decreased hematocrit, decreased hepatocyte number, decreased insulin secretion, decreased pancreatic beta cell proliferation, decreased susceptibility to induced muscular atrophy, decreased total fat pad weight, delayed hair appearance, endocrine/exocrine gland phenotype, exocrine pancreas hypoplasia, eyelids fail to open, homeostasis/metabolism phenotype, impaired hematopoiesis, improved glucose tolerance, increased circulating glucose level, increased insulin secretion, increased insulin sensitivity, increased lens epithelium apoptosis, increased mean corpuscular hemoglobin, increased pancreatic beta cell mass, increased pancreatic beta cell proliferation, increased physiological sensitivity to xenobiotic, muscle phenotype, pale liver, perinatal lethality, incomplete penetrance, postnatal lethality, incomplete penetrance, reduced male fertility, ruffled hair [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (48 sources): abnormal bone mineralization, abnormal calcium ion homeostasis, abnormal clavicle morphology, abnormal embryo size, abnormal frontal bone morphology, abnormal glycogen homeostasis, abnormal lens fiber morphology, abnormal mean corpuscular hemoglobin, abnormal mean corpuscular volume, abnormal neurocranium morphology, [+]