| Monarch Ortholog Phenotypes
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Human (15 sources):
Abdominal pain,
Anterior uveitis,
Arthralgia,
Autoimmunity,
Elevated circulating C-reactive protein concentration,
Elevated erythrocyte sedimentation rate,
Fever,
Hepatomegaly,
Joint swelling,
Juvenile rheumatoid arthritis,
[+]
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Mouse (11 sources):
abnormal cellular respiration,
abnormal macrophage physiology,
abnormal oxidative phosphorylation,
abnormal redox activity,
decreased circulating interleukin-1 beta level,
decreased circulating tumor necrosis factor level,
decreased fatty acids level,
decreased interleukin-1 beta secretion,
decreased susceptibility to endotoxin shock,
increased circulating interleukin-1 beta level,
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.