| Monarch Ortholog Phenotypes
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Human (2 sources):
Immunodeficiency,
Lymphopenia
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Mouse (34 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD4-positive, alpha beta T cell morphology,
abnormal CD8-positive, alpha beta T cell morphology,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal CD8-positive, alpha-beta T cell number,
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology,
abnormal Peyer's patch morphology,
abnormal cell migration,
abnormal class switch recombination,
abnormal hematopoietic system morphology/development,
abnormal humoral immune response,
abnormal leukocyte migration,
abnormal spleen white pulp morphology,
decreased B-1a cell number,
decreased B-1b cell number,
decreased CD4-positive, alpha beta T cell number,
decreased CD8-positive, naive alpha-beta T cell number,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased response to antigen,
decreased single-positive T cell number,
immune system phenotype,
impaired hematopoiesis,
increased B-1 B cell number,
increased CD8-positive, alpha-beta T cell number,
increased NK cell number,
increased alpha-beta T cell number,
increased central memory CD4-positive, alpha-beta T cell number,
increased central memory CD8 positive, alpha-beta T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased macrophage cell number,
increased neutrophil cell number,
increased sensitivity to xenobiotic induced morbidity/mortality,
increased single-positive T cell number
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.